CMAI was founded in 2020 with a goal to provide unique learning experiences for students and postdocs and to foster ties between Academia, National Labs, Industry, and Government. 

The Center focuses on artificial intelligence, big data, control, optimization, anomalous (nonlocal) diffusion, nonlinear partial differential equations, with a broad range of applications. CMAI is funded by George Mason University, National Science Foundation, Department of Energy, Defense Threat Reduction Agency, Air Force Office of Scientific Research, Army Research Office, and Department of Navy.

CMAI stimulates research by bringing GMU faculty and students close to well-known scholars.  It organizes conferences and workshops and supports a visitor program. It supports educational programs via tutorials, summer schools, and active involvement in Department of Mathematical Sciences graduate program.